A Chemical Ionization Ion Source for Mass Spectrometer

Tuning of an electrospray ionization source for maximum peptide-ion transmission into a mass spectrometer.

We describe assembly and optimization of a continuous flow nanoelectrospray source for high-performance analysis on a routine basis. It is derived from an inJection adaptable Fine Ionization Source ("JaFIS"), previously shown to be durable and easy to use (Geromanos, S.; et al. Rapid Commun. Mass Spectrom. 1998, 12, 551-556) and now modified for maximum sensitivity. Proper design, manufacturing...

A Chemical Ionization Mass Spectrometer for Ambient Measurements of Ammonia

This study presents a chemical ionization mass spectrometer (CIMS) for fast response, in-situ measurements of gas phase ammonia (NH3). The NH3 background level detected with the CIMS ranged between 0.3–1 ppbv, with an uncertainty of 30 pptv under optimized conditions. The instrument sensitivity varied from 4–25 Hz/pptv for >1 MHz of reagent ion signals (protonated ethanol ions), with a 30% unce...

MEMS ion source for mass spectrometer integrated on a chip

A field-deployable, chemical ionization time-of-flight mass spectrometer

We constructed a new chemical ionization timeof-flight mass spectrometer (CI-TOFMS) that measures atmospheric trace gases in real time with high sensitivity. We apply the technique to the measurement of formic acid via negative-ion proton transfer, using acetate as the reagent ion. A novel high pressure interface, incorporating two RF-only quadrupoles is used to efficiently focus ions through f...

Performance of a corona ion source for measurement of sulfuric acid by chemical ionization mass spectrometry

The performance of an ion source based on corona discharge has been studied. This source is used for the detection of gaseous sulfuric acid by chemical ionization mass spectrometry (CIMS) through the reaction of NO−3 ions with H2SO4. The ion source is operated under atmospheric pressure and its design is similar to the one of a radioactive (americium-241) ion source which has been used previous...